Basic Information

IDDRAMP01623
SequenceLIGPVLGLVGSALGGLLKKI
Length20
NameBombinin-H4 (bombinin H isomers; Frogs, amphibians, animals)
SourceBombina variegata (European frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, hemolytic against mammalian cells, Antifungal
Pathogen[Ref.8223491] Gram-negative bacterium: Escherichia coli D21 (MIC=4.8 µM);##Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.3 µM).
Hemolytic Activity[Ref.8223491] Lethal concentration is 14.6 µM against human red blood cell.
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P82284
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8223491

Physicochemical Properties

Residues20
SequenceLIGPVLGLVGSALGGLLKKI
Molecular Weight1918.41
Grand Average of Hydropathy1.49
Isoelectric Point10.003
Charge at pH 7.41.552
Secondary StructureHelix: 0.500, Turn: 0.350, Sheet: 0.350
Instability Index12.565
Aromaticity0

Similar Structure Search

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