Basic Information

IDDRAMP01787
SequenceAILTTLANWARKFL
Length14
NameTemporin-HN1 (Frogs, amphibians, animals)
SourceOdorrana hainanensis (Hainan odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=37.5 µM), Staphylococcus carnosus KHS (MIC=37.5 µM), Bacillus licheniformis X39 (MIC=19 µM), Rhodococcus rhodochrous X15 (MIC=4.8 µM);##Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=75 µM);##Fungi: Slime mould 090223 (MIC=19 µM), Candida albicans ATCC2002 (MIC=75 µM).
Hemolytic Activity[Ref:22450466]IC50=75 µM against washed human erythrocytes
Cytotoxicity[Ref.22450466]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot E7EKD0
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22450466

Physicochemical Properties

Residues14
SequenceAILTTLANWARKFL
Molecular Weight1617.931
Grand Average of Hydropathy0.707
Isoelectric Point11.001
Charge at pH 7.41.605
Secondary StructureHelix: 0.429, Turn: 0.071, Sheet: 0.429
Instability Index4.9
Aromaticity0.143

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