Basic Information
| ID | DRAMP01301 |
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| Sequence | FLSLIPHAINAVSAIAKHN |
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| Length | 19 |
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| Name | Phylloseptin-1 (PS-1; Frogs, amphibians, animals) |
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| Source | Phyllomedusa hypochondrialis (Orange-legged leaf frog) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal |
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| Pathogen | [Ref.15752569]Gram-positive bacteria: Staphylococcus aureus (MIC=7.9 µM), Enterococcus faecalis (MIC=4.0 µM);##Gram-negative bacteria: Escherichia coli (MIC=7.9 µM), Psecdomonas aeruginosa (MIC=4 µM), Psecdomonas aeruginosa wt (MIC=3 µM). |
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| Hemolytic Activity | [Ref:15752569]0.3% hemolytic activity at 4 μM, 0.57% hemolytic activity at 8 μM, 0.6% hemolytic activity at 16 μM, 0.98% hemolytic activity at 32 μM, 1.98% hemolytic activity at 64 μM against human red blood cells |
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| Cytotoxicity | [REf.15752569]No cytotoxicity information found##[Ref.18656510]No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
P84566 |
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| PDB |
2JQ0 |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 15752569, 18656510 |
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