Basic Information

IDDRAMP02077
SequenceFLPIIAGIAAKVFPKIFCAISKKC
Length24
NameBrevinin-1Pb (Frogs, amphibians, animals)
SourceRana pipiens (Northern leopard frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=5 μM);##Gram-negative bacterium: Escherichia coli (MIC=14 μM).##Yeast: Candida albicans (MIC=7 μM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization of a C-terminal Cys residue (forming a disulfide bond)
Linear/Cyclic/BranchedCyclic
Uniprot Q8QFQ5
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10651828, 12413397

Physicochemical Properties

Residues24
SequenceFLPIIAGIAAKVFPKIFCAISKKC
Molecular Weight2579.259
Grand Average of Hydropathy1.296
Isoelectric Point9.701
Charge at pH 7.43.498
Secondary StructureHelix: 0.417, Turn: 0.167, Sheet: 0.208
Instability Index15.021
Aromaticity0.125

Similar Structure Search

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