Basic Information

IDDRAMP02289
SequenceFVGPVLKIAAGILPTAICKIYKKC
Length24
NameGaegurin-RN4 (Frogs, amphibians, animals)
SourceRana nigrovittata
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
Pathogen[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=1.17 µg/ml), Staphylococcus aureus ATCC43300 (MIC=9.38 µg/ml), Bacillus subtilis (MIC=2.34 µg/ml);##Yeast: Candida albicans ATCC2002 (MIC=2.34 µg/ml).
Hemolytic Activity[Ref.19778602] It has 18.64 ± 0.25% hemolytic activity at 100 μg/ml against rabbit red blood cells
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys18 and Cys24)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19778602

Physicochemical Properties

Residues24
SequenceFVGPVLKIAAGILPTAICKIYKKC
Molecular Weight2547.216
Grand Average of Hydropathy1.067
Isoelectric Point9.595
Charge at pH 7.43.496
Secondary StructureHelix: 0.417, Turn: 0.167, Sheet: 0.208
Instability Index15.971
Aromaticity0.083

Similar Structure Search

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