Basic Information

IDDRAMP02357
SequenceFLGALIKGAIHGGRFIHGMIQNHH
Length24
NamePleurocidin-like peptide WF3 (NRC-5; fish, chordates, animals)
SourcePseudopleuronectes americanus (Winter flounder 3)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Aeromonas salmonicida 99-1 (MIC>64 µg/ml), A. salmonicida 97-4 (MIC>64 µg/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=64 µg/ml), Salmonella enterica serovar Typhimurium 14028s (MIC>64 µg/ml), Pseudomonas aeruginosa K799 (MIC>64 µg/ml), Pseudomonas aeruginosa Z61 (MIC=32 µg/ml), Escherichia coli CGSC 4908 (MIC=64 µg/ml), Escherichia coli UB1005 (MIC=64 µg/ml), Escherichia coli DC2 (MIC>64 µg/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC=32 µg/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 µg/ml).##Yeast: Candida albicans C627 (MIC>64 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q90VW7
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12878506, 11113283

Physicochemical Properties

Residues24
SequenceFLGALIKGAIHGGRFIHGMIQNHH
Molecular Weight2625.064
Grand Average of Hydropathy0.271
Isoelectric Point11.001
Charge at pH 7.41.701
Secondary StructureHelix: 0.333, Turn: 0.250, Sheet: 0.208
Instability Index2.217
Aromaticity0.083

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.