| ID | DRAMP02438 |
|---|---|
| Sequence | FWGHIWNAVKRVGANALHGAVTGALS |
| Length | 26 |
| Name | Halocyntin |
| Source | Halocynthia papillosa (Red sea-squirt) |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.19085906]Gram-positive bacteria (Native, Synthetic): Micrococcus luteus A270 (MBC=0.39-0.78, 0.39-0.78 µM), Aerococcus viridans 54.145 T (MBC=3.13-6.25, 0.78-1.56 µM), Bacillus megaterium 66.20 T (MBC=0.75-1.56, 0.39-0.78 µM), Staphylococcus aureus 65.8 T (MBC=6.25-12.50, 1.56-3.13 µM), Enterococcus faecalis 103015 T (MBC=6.25-12.50, 1.56-3.13 µM);##Gram-negative bacteria (Native, Synthetic): Enterobacter aerogenes 30.86 T (MBC=25-50, 6.25-12.50 µM), Pseudomonas aeruginosa 100720 T (MBC>100, 25-50 µM), Salmonella thyphimurium 60.62 T (MBC=50-100, 12.50-25 µM), Klebsiella pneumoniae 82.91 T (MBC=12.50-25, 1.56-3.13 µM), Neisseria gonorrhoeae 103711 (MBC=25-50, ND µM), Escherichia coli (MBC=6.25-12.50, 6.25-12.50 µM). |
| Hemolytic Activity | [Ref.19085906]8% hemolytic activity at 6.25 μM, 13% hemolytic activity at 12.5 μM, 14% hemolytic activity at 25 μM, 22% hemolytic activity at 50 μM against sheep erythrocytes |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | P86415 |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 19085906 |
Physicochemical Properties
| Residues | 26 |
|---|---|
| Sequence | FWGHIWNAVKRVGANALHGAVTGALS |
| Molecular Weight | 2733.092 |
| Grand Average of Hydropathy | 0.377 |
| Isoelectric Point | 11.001 |
| Charge at pH 7.4 | 1.628 |
| Secondary Structure | Helix: 0.346, Turn: 0.269, Sheet: 0.269 |
| Instability Index | 15.123 |
| Aromaticity | 0.115 |