Basic Information

IDDRAMP02454
SequenceGCFEDWSRCSPSTASATGVLWRSCDSYCKVCFKADRGECYDSPSLNCPHRLPNNKQCRCINARTAKDNRNPTCWA
Length75
NameTheromacin (Arthropods, animals)
SourceHirudo medicinalis (Medicinal leech)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacterium: Escherichia coli ATCC 35218 (LD90=6.25 µg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 12600 (LD90=25 µg/ml), Bacillus megaterium ATCC 14581 (MBC=0.2-0.39 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot A8I0L8, A8IK85
PDB 2LN8
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22396551, PubMed ID is not available

Physicochemical Properties

Residues75
SequenceGCFEDWSRCSPSTASATGVLWRSCDSYCKVCFKADRGECYDSPSLNCPHRLPNNKQCRCINARTAKDNRNPTCWA
Molecular Weight8453.43
Grand Average of Hydropathy-0.764
Isoelectric Point8.599
Charge at pH 7.43.338
Secondary StructureHelix: 0.173, Turn: 0.293, Sheet: 0.147
Instability Index65.867
Aromaticity0.093

Similar Structure Search

Candidates based on structure

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