Basic Information

IDDRAMP02470
SequenceSCTTCECCCSCS
Length12
NameNosiheptide (NOS; Antibiotic 9671-RP)
SourceStreptomyces actuosus
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus strain 209P (MIC=0.0009 µg/ml), S. aureus strain 133 (MIC=0.0019 µg/ml), S. aureus strain B3 (MIC=0.003 µg/ml), S. aureus strain Hb (MIC=0.003 µg/ml), Micrococcus citreus strain ATCC 8411 (MIC=0.0038 µg/ml), M. lysodeikticus strain ATCC 4698 (MIC=0.003 µg/ml), Sarcina Lutea strain ATCC 9341 (MIC=0.0011 µg/ml), Streptococcus faecalis strain ATCC 9790 (MIC=0.0007 µg/ml), S. viridans (MIC=0.0065 µg/ml), Streptococcus pyogenes hemolyticus strain Dig7 (MIC=0.00028 µg/ml), Diplococcus pneumoniae strain Til (MIC=0.00015 µg/ml), N. catrrhalis (MIC=0.0017 µg/ml), Lactobacillus casei strain ATCC 6633 (MIC=0.003 µg/ml), Bacillus cereus ATCC 6630 (MIC=0.0071 µg/ml) and various isolates of Listeria monocytogenes.##Gram-negative bacterium: P. multocida strain A125 (MIC=0.0024 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot C6FX52
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19678698, 18406324

Physicochemical Properties

Residues12
SequenceSCTTCECCCSCS
Molecular Weight1229.426
Grand Average of Hydropathy0.642
Isoelectric Point4.05
Charge at pH 7.4-1.893
Secondary StructureHelix: 0.000, Turn: 0.250, Sheet: 0.083
Instability Index127.283
Aromaticity0

Similar Structure Search

Candidates based on structure

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