Basic Information

IDDRAMP02521
SequenceKFFKKLKNSVKKRAKKFFKKPRVIGVSIPF
Length30
NameCathelicidin-OH (Cathelicidin-related protein; Snakes, reptiles, animals)
SourceOphiophagus hannah (King cobra) (Naja hannah)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram+, Antifungal
Pathogen[Ref.18620012]Gram-negative bacteria: Escherichia coli ATCC 25922, Escherichia coli ML-35P, Escherichia coli clinic strain, Pseudomonas aeruginosa ATCC 27853, Pseudomonas aeruginosa PA 01, Pseudomonas aeruginosa clinic strain, Enterobacter aerogenes clinic strain, Enterobacter cloacae clinic strain.##[Ref.22491685]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=3.125 μg/ml), Staphylococcuss aureus ATCC 43300 MRSA (MIC=6.25 μg/ml), Staphylococcuss aureus clinical strain 1 (MIC=3.125 μg/ml), Staphylococcuss aureus clinical strain 2 (MIC=6.25 μg/ml), Staphylococcuss aureus clinical strain 3 (MIC=6.25 μg/ml), Enterococcus faecalis ATCC 29212 (MIC=25 μg/ml) ;##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=6.25 μg/ml), Escherichia coli ML-35p (MIC=3.125 μg/ml), Escherichia coli clinical strain 1 (MIC=6.25 μg/ml), Escherichia coli clinical strain 2 (MIC=3.125 μg/ml), Escherichia coli clinical strain 3 (MIC=1.56 μg/ml), Escherichia coli clinical strain 4 (MIC=12.5 μg/ml), Escherichia coli clinical strain 5 (MIC=3.125 μg/ml), Escherichia coli clinical strain 6 (MIC=3.125 μg/ml), Enterobacter cloacae ATCC 13047 (MIC=25 μg/ml), Enterobacter cloacae clinical strain (MIC=3.125 μg/ml), Enterobacter aerogenes clinical strain (MIC=6.25 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=6.25 μg/ml), Pseudomonas aeruginosa PA 01 (MIC=6.25 μg/ml), Pseudomonas aeruginosa clinical strain 1 (MIC=12.5 μg/ml), Pseudomonas aeruginosa clinical strain 2 (MIC=6.25 μg/ml), Haemophilus influenzae ATCC 49247 (MIC=3.125 μg/ml), Haemophilus influenzae ATCC 49766 (MIC=3.125 μg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=6.25 μg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=3.125 μg/ml) ;##Fungi : Candida albicans ATCC 2002 (MIC>200 μg/ml), Candida albicans clinical strain (MIC>200 μg/ml)
Hemolytic Activity[Ref.22491685] 3% hemolysis at 100 μg/ml , 5% hemolysis at 200 μg/ml , 6% hemolysis at 300 μg/ml , 7% hemolysis at 400 μg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot B6S2X2
PDB 2mwt resolved by NMR
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18620012, 22491685

Physicochemical Properties

Residues30
SequenceKFFKKLKNSVKKRAKKFFKKPRVIGVSIPF
Molecular Weight3595.461
Grand Average of Hydropathy-0.517
Isoelectric Point12
Charge at pH 7.411.532
Secondary StructureHelix: 0.367, Turn: 0.200, Sheet: 0.067
Instability Index4.327
Aromaticity0.167

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.