Basic Information

IDDRAMP29044
SequenceKFFRKLKKSVKKRAKKFFKKPRVIGVSIPF
Length30
NameCbf-K-16 (variant of BF-30)
SourceSynthetic construct (Cbf-K16 is a variant of BF-30, which was found in the venom of the snake bungarus fasciatus)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.31704464] Gram-negative drug-resistant clinical isolates: H. pylori SS1 (MIC = 16 μg/mL, MBC = 32 μg/mL); Gram -negative bacteria: H. pylori 26695 (MIC = 32 μg/mL, MBC = 64 μg/mL), H. pylori 11637 (MIC = 16 μg/mL, MBC = 64 μg/mL) ##[Ref.27287456] Gram-positive drug-resistant clinical isolates: MRSA strain no.1 (MIC = 32 μg/mL), MRSA strain no.2 (MIC = 16 μg/mL), S.aureus strain no.1 (MIC = 16 μg/mL), S.aureus strain no.2 (MIC = 64 μg/mL), S.aureus strain no.3 (MIC = 8 μg/mL), S.aureus strain no.4 (MIC = 16 μg/mL), S.aureus strain no.5 (MIC = 4 μg/mL), S.aureus strain no.6 (MIC = 8 μg/mL), S.aureus strain no.7 (MIC = 32 μg/mL), S.epidermidis strain no.1 (MIC = 16 μg/mL), S.epidermidis strain no.2 (MIC = 32 μg/mL);## Gram-positive bacteria: S.aureus ATCC 25923 (MIC = 8 μg/mL);## Gram-negative drug-resistant clinical isolates: E.coli strain no.1 (MIC = 4 μg/mL), E.coli strain no.2 (MIC = 8 μg/mL), E.coli strain no.3 (MIC = 8 μg/mL); ##Gram-negative bacteria: E.coli ATCC 25922 (MIC = 4 μg/mL)
Hemolytic Activity[Ref.27287456]Cbf-K-16 has low hemolytic activity
Cytotoxicity[Ref.27287456] Cbf-K-16 has low cytotoxicity.
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31704464, 27287456

Physicochemical Properties

Residues30
SequenceKFFRKLKKSVKKRAKKFFKKPRVIGVSIPF
Molecular Weight3637.544
Grand Average of Hydropathy-0.55
Isoelectric Point12
Charge at pH 7.412.532
Secondary StructureHelix: 0.367, Turn: 0.167, Sheet: 0.067
Instability Index9.337
Aromaticity0.167

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