Basic Information
| ID | DRAMP20883 |
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| Sequence | KRFKKFFRKLKKSVKKRKKEFKKKPRVIKVSIPF |
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| Length | 34 |
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| Name | Cath-A |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.29392557] Gram-positive bacteria: MRSA PS-2 (MIC=64 μg/ml);##Gram-negative bacteria, MRSA PS-7 (MIC=64 μg/ml), MRSA PS-18 (MIC=32 μg/ml), MRSA PS-45 (MIC=32 μg/ml), MRSA PS-46 (MIC=32 μg/ml), MRSA PS-50 (MIC=32 μg/ml), MRSA PS-59 (MIC=64 μg/ml), MRSA PS-70 (MIC=32 μg/ml), MRSA PS-84 (MIC=128 μg/ml), MRSA PS-106 (MIC=32 μg/ml), MRSA PS-131 (MIC=128 μg/ml), MRSA PS-139 (MIC=32 μg/ml), MRSA PS-162 (MIC=128 μg/ml), MRSA PS-165 (MIC=32 μg/ml), Staphylococcus aureus ATCC 25923 (MIC=32 μg/ml), Staphylococcus aureus ATCC 33591 (MIC=128 μg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8 μg/ml), Escherichia coli ATCC 51446 (MIC=16 μg/ml), Klebsiella pneumoniae ATCC 700603 (MIC=64 μg/ml), Klebsiella pneumoniae ATCC 13883 (MIC=16 μg/ml) |
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| Hemolytic Activity | [Ref.29392557] 0% haemolysis at 1.0 μg/ml, 0% haemolysis at 2.0 μg/ml, 0% haemolysis at 4.0 μg/ml, 0% haemolysis at 8.0 μg/ml, 0% haemolysis at 16.0 μg/ml, 0% haemolysis at 31.2 μg/ml, 2% haemolysis at 62.5 μg/ml, 4% haemolysis at 125.0 μg/ml, 15% haemolysis at 250.0 μg/ml, 23% haemolysis at 500.0 μg/ml, 53% haemolysis at 1000.0 μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.29392557] The cell viability of HUVEC is 132%, 99% and 79% at peptide concentrations of 35.5, 71 and 113 μg/ml .## The cell viability of H9c2is 129%, 97%, and 80% at peptide concentrations of 35.5, 71, and 113 μg/ml . |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 29392557 |
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