Basic Information

IDDRAMP02644
SequenceRCICTRGFCRCICTRGFC
Length18
NameRhesus theta-defensin 3 (RTD-3; primates, mammals, animals)
SourceMacaca mulatta (Rhesus macaque)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral
PathogenGram-positive bacteria: Staphylococcus aureus 502a, Listeria monocytogenes;##Gram-negative bacteria: Salmonella typhimurium, Escherichia coli ML35.##Fungi: Candida albicans 16820, Cryptococcus neoformans 271A (the activity of RTD-2 against Escherichia coli ML35 was 2-3-fold less than those of RTD-1 and RTD-3).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P82270, Q9TU01
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10521339, 1152799, 11675394

Physicochemical Properties

Residues18
SequenceRCICTRGFCRCICTRGFC
Molecular Weight2098.589
Grand Average of Hydropathy0.522
Isoelectric Point9.008
Charge at pH 7.43.41
Secondary StructureHelix: 0.222, Turn: 0.111, Sheet: 0.000
Instability Index36.233
Aromaticity0.111

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