Basic Information
| ID | DRAMP02970 |
|---|
| Sequence | RGGRLCYCRRRFCVCVGR |
|---|
| Length | 18 |
|---|
| Name | Protegrin-1 (Protegrin 1; PG-1; pigs, mammals, animals) |
|---|
| Source | Sus scrofa (Pig) |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
|---|
| Pathogen | Gram-negative bacteria: Escherichia coli (MIC=64 µg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=64 µg/ml), Staphylococcus epidermidis (MIC=2 µg/ml). |
|---|
| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
|---|
| Cytotoxicity | [Ref.31399625] Cytotoxicity: 661W cells(IC50=353.4±70.5μM), HEK293T cells(IC50=2760±54.1μM), NIH-3T3 cells(IC50=719.2±59.5μM), SH-SY5Y cells(IC50=590.4±58.2μM), PMN cells(IC50=948.9±64.1μM), and 3D4/2 cells(IC50=391.1±71.3μM) |
|---|
| N-terminal Modification | Free |
|---|
| C-terminal Modification | Free |
|---|
| Linear/Cyclic/Branched | Cyclic |
|---|
| Uniprot |
P32194 |
|---|
| PDB |
1PG1 |
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 8647100 |
|---|
