Basic Information

IDDRAMP03024
SequenceLKLKSIVSWAKKVL
Length14
NameMastoparan B (MP-B; insects, arthropods, invertebrates, animals)
SourceVespa basalis (Hornet)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti Mammalian cells, Anti-cancer
Pathogen[Ref.10667861] Gram-positive bacteria: Staphylococcus epidermidis ATTC 12228 (MIC=25 µM), Bacillus subtilis PCI 219 (MIC=25 µM), Enterococcus faecium EFMY-28 (MIC=12.5 µM);##Gram-negative bacterium: Escherichia coli NIHJ JC-2 (MIC=50 µM)
Hemolytic Activity[Ref.10667861] 68.2% hemolysis at the peptide concentration of 100 µM is , 27.9% Hemolysis at 50 µM against human red blood cells.
Cytotoxicity[Ref.10667861]No cytotoxicity information found##[Ref.8555423]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P21654
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10667861, 8555423

Physicochemical Properties

Residues14
SequenceLKLKSIVSWAKKVL
Molecular Weight1613.039
Grand Average of Hydropathy0.571
Isoelectric Point10.478
Charge at pH 7.43.547
Secondary StructureHelix: 0.500, Turn: 0.143, Sheet: 0.286
Instability Index-31.771
Aromaticity0.071

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.