Basic Information

IDDRAMP03279
SequenceKIKWFKTMKSIAKFIAKEQMKKHLGGE
Length27
NameM-lycotoxin-Hc2a (M-LCTX-Hc2a; Lycotoxin-2; Lycotoxin II; spiders, Arthropods, animals)
SourceHogna carolinensis (Carolina wolf spider) (Lycosa carolinensis)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus thuringiensis subsp. Israelensis (MIC=10-60 µM);##Gram-negative bacteria: Escherichia coli D31 (MIC<10 µM), Escherichia coli DH5 (MIC<40 µM).##Fungi: Candida glabrata ATCC 2001 (MIC=100-150 µM)
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P61508
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9442044, 18098329

Physicochemical Properties

Residues27
SequenceKIKWFKTMKSIAKFIAKEQMKKHLGGE
Molecular Weight3206.91
Grand Average of Hydropathy-0.659
Isoelectric Point10.222
Charge at pH 7.45.578
Secondary StructureHelix: 0.259, Turn: 0.111, Sheet: 0.259
Instability Index6.685
Aromaticity0.111

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