Basic Information

IDDRAMP03463
SequenceGLVRKGGEKFGEKLRKIGQKIKEFFQKLALEIEQ
Length34
NamerCRAMP (rat cathelin-related antimicrobial peptide; Rodents, mammals, animals)
SourceRattus norvegicus (Norway rat)
ActivityAntimicrobial, Antibacterial
Pathogen[No NaCl]: Escherichia coli DH5a (MIC=0.54 µM), E. coli ML-35p (MIC=1.55 µM), Pseudomonas aeruginosa PAO1 (MIC=0.69 µM), Pseudomonas aeruginosa MR3007 (MIC=2.01 µM); Staphylococcus aureus ATCC (MRSA) 33591 (MIC=3.19 µM), Staphylococcus aureus 93918 (MIC=2.14 µM).##[100 mM NaCl]: Escherichia coli DH5a (MIC=0.61 µM), Escherichia coli ML-35p (MIC=0.66 µM), Pseudomonas aeruginosa PAO1 (MIC=1.17 µM), Pseudomonas aeruginosa MR3007 (MIC=1.78 µM), Staphylococcus aureus ATCC (MRSA) 33591 (MIC>20.1 µM), Staphylococcus aureus 93918 (MIC=2.16 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10768969

Physicochemical Properties

Residues34
SequenceGLVRKGGEKFGEKLRKIGQKIKEFFQKLALEIEQ
Molecular Weight3946.64
Grand Average of Hydropathy-0.682
Isoelectric Point9.872
Charge at pH 7.43.545
Secondary StructureHelix: 0.324, Turn: 0.147, Sheet: 0.294
Instability Index23.835
Aromaticity0.088

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