| ID | DRAMP04077 |
|---|---|
| Sequence | AKKVFKRLEKLFSKIWNDK |
| Length | 19 |
| Name | Anal 2 (antimicrobial peptide HP (2-20)analogue) |
| Source | Synthetic construct (amino acid substitution) |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
| Pathogen | Gram-positive bacteria: Bacillus subtilis (MIC=1.56 µg/ml), Staphylococcus epidermidis (MIC=3.13 µg/ml), Staphylococcus aureus (MIC=6.25 µg/ml), Listeria monocytogenes (MIC=1.56 µg/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 µg/ml), Salmonella typhimurium (MIC=0.78 µg/ml), Proteus vulgaris (MIC=3.13 µg/ml), Pseudomonas aeruginosa (MIC=6.25 µg/ml), Escherichia coli O157 (MIC=6.25 µg/ml).##Fungi: Trichosporon beigelii (MIC=1.56 µg/ml), Candida albicans (MIC=25 µg/ml), Saccharomyces cerevisiae (MIC=25 µg/ml), Aspergillus flavus (MIC=50 µg/ml), Aspergillus fumigatus (MIC>50 µg/ml), Botrytis cinerea (MIC=6.25 µg/ml), Fusarium moniliforme (MIC=25 µg/ml). |
| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | P56029 |
| PDB | 1P0L |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 16255716, PubMed ID is not available |
Physicochemical Properties
| Residues | 19 |
|---|---|
| Sequence | AKKVFKRLEKLFSKIWNDK |
| Molecular Weight | 2378.855 |
| Grand Average of Hydropathy | -0.863 |
| Isoelectric Point | 10.295 |
| Charge at pH 7.4 | 4.594 |
| Secondary Structure | Helix: 0.368, Turn: 0.105, Sheet: 0.211 |
| Instability Index | 7.342 |
| Aromaticity | 0.158 |
