Basic Information

IDDRAMP04081
SequenceAKKVFKRLEKLFSKIFNFK
Length19
NameAnal 6 (antimicrobial peptide HP (2-20)analogue)
SourceSynthetic construct (amino acid substitution)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus subtilis (MIC=1.56 µg/ml), Staphylococcus epidermidis (MIC=6.25 µg/ml), Staphylococcus aureus (MIC=3.13 µg/ml), Listeria monocytogenes (MIC=0.78 µg/ml);##Gram-negative bacteria: Escherichia coli (MIC=3.13 µg/ml), Salmonella typhimurium (MIC=0.39 µg/ml), Proteus vulgaris (MIC=3.125 µg/ml), Pseudomonas aeruginosa (MIC=6.25 µg/ml), Escherichia coli O157 (MIC=6.25 µg/ml).##Fungi: Trichosporon beigelii (MIC=3.13 µg/ml), Candida albicans (MIC>25 µg/ml), Saccharomyces cerevisiae (MIC=25 µg/ml), Aspergillus flavus (MIC=50 µg/ml), Aspergillus fumigatus (MIC=50-25 µg/ml), Botrytis cinerea (MIC=12.5 µg/ml), Fusarium moniliforme (MIC=12.5 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P56029
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16255716, PubMed ID is not available

Physicochemical Properties

Residues19
SequenceAKKVFKRLEKLFSKIFNFK
Molecular Weight2371.906
Grand Average of Hydropathy-0.337
Isoelectric Point10.676
Charge at pH 7.45.594
Secondary StructureHelix: 0.421, Turn: 0.105, Sheet: 0.211
Instability Index-10.505
Aromaticity0.211

Similar Structure Search

Candidates based on structure

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