Basic Information

IDDRAMP02855
SequenceGRFKRFRKKFKKLFKKLSPVIPLLHLG
Length27
NameCathelicidin-6 (Antibacterial peptide BMAP-27, Myeloid antib
SourceBos taurus (Bovine)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC25922 (MIC=1 µg/ml), E. coli ML35 (MIC=1 µg/ml), E. coli D21 (MIC=0.25 µg/ml), Salmonella typhimurium ATCC 14028 (MIC=1 µg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=1 µg/ml), Serratia marcescens ATCC 8100 (MIC=2 µg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 µg/ml), Staphylococcus aureus Cowan 1 (MIC=2 µg/ml), Staphylococcus aureus (MRSA) (MIC=4 µg/ml), S. epidermidis ATCC 12228 (MIC=1 µg/ml), Bacillus megaterium Bm11 (MIC=2 µg/ml).##Fungi: Candida albicans (MIC=8 µg/ml), Cryptococcus neoformans (MIC=4 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P54228, B9UKM5
PDB 2KET
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8910461, 19136450, PubMed ID is not available

Physicochemical Properties

Residues27
SequenceGRFKRFRKKFKKLFKKLSPVIPLLHLG
Molecular Weight3283.1
Grand Average of Hydropathy-0.367
Isoelectric Point12
Charge at pH 7.49.576
Secondary StructureHelix: 0.407, Turn: 0.185, Sheet: 0.185
Instability Index21.056
Aromaticity0.148

Similar Structure Search

Candidates based on structure

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