| ID | DRAMP02962 |
|---|---|
| Sequence | GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLGCG |
| Length | 36 |
| Name | PMAP-36 |
| Source | Sus scrofa |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.27251456] Gram-positive bacteria: Staphylococcus aureus 29213 (MIC=2 μM, MBC=4 μM), Staphylococcus aureus 25923 (MIC=2 μM, MBC=4 μM), Staphylococcus epidermidis 12228 (MIC=2 μM, MBC=4 μM), Bacillus subtilis 63501 (MIC=1 μM, MBC=1 μM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=1 μM, MBC=4 μM), Escherichia coli EC183 (MIC=1 μM, MBC=1 μM), Escherichia coli 1005 (MIC=2 μM, MBC=2 μM), Salmonella typhimurium C77-31 (MIC=1 μM, MBC=2 μM);##Fungi: Candida albicans 2.2086 (MIC=128 μM, MFC=128 μM), Candida albicans CA276 (MIC=128 μM, MFC=128 μM), Candida tropicalis 2.1975 (MIC=1 μM, MFC=2 μM), Candida krusei 2.1857 (MIC=8 μM, MFC=8 μM). |
| Hemolytic Activity | [Ref.27251456] 5% hemolysis at 4 µM, MHC=4 µM against human red blood cells. |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | P49931 |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 27251456 |
Physicochemical Properties
| Residues | 36 |
|---|---|
| Sequence | GRFRRLRKKTRKRLKKIGKVLKWIPPIVGSIPLGCG |
| Molecular Weight | 4157.168 |
| Grand Average of Hydropathy | -0.461 |
| Isoelectric Point | 12 |
| Charge at pH 7.4 | 12.515 |
| Secondary Structure | Helix: 0.333, Turn: 0.250, Sheet: 0.111 |
| Instability Index | 27.281 |
| Aromaticity | 0.056 |