Basic Information

IDDRAMP20824
SequenceGLFKKLRRKIKKGFKKIFKRLPPIGVGVSIPLAGKR
Length36
NameAM-CATH36
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.28089718] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=21μg/ml), Staphylococcus aureus ATCC 33592 (MIC=21μg/ml);##Gram-negative bacteria:Acinetobacter baumannii ATCC 9955 (MIC=5.2μg/ml), Acinetobacter baumannii ATCC BAA-1794 (MIC=5.2μg/ml), Escherichia coli ATCC 4157 (MIC=140μg/ml), K. pneumoniae ATCC 33495 (MIC=5.2μg/ml), K. pneumoniae ATCC BAA-1705 (MIC=5.6μg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=5.2μg/ml), Pseudomonas aeruginosa ATCC BAA-2110 (MIC=5.2μg/ml)
Hemolytic Activity[Ref.28089718] 0% hemolysis at 300μg/ml against sheep red cells
Cytotoxicity[Ref.28089718] The survival rate of A549 human lung epithelial cells is 124% at a peptide concentration of 300 μg/ml
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID28089718

Physicochemical Properties

Residues36
SequenceGLFKKLRRKIKKGFKKIFKRLPPIGVGVSIPLAGKR
Molecular Weight4076.11
Grand Average of Hydropathy-0.247
Isoelectric Point12
Charge at pH 7.412.535
Secondary StructureHelix: 0.361, Turn: 0.250, Sheet: 0.139
Instability Index29.961
Aromaticity0.083

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.