Basic Information

IDDRAMP04174
SequenceKWLKKWL
Length7
NameL2K3W2 (LlKmW2 model peptides)
SourceSynthetic construct (De novo design)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: B. subtilis (MIC=80 µg/ml), S. aureus (MIC=80 µg/ml), S. epidermis (MIC>80 µg/ml), M. luteus (MIC>80 µg/ml), S. aureus (MRSA) (MIC>80 µg/ml).##Gram-negative bacteria: E. coli (MIC>80 µg/ml), S. dysentariae (MIC>80 µg/ml), S. typhimorium (MIC>80 µg/ml), K. pneumoniae (MIC>80 µg/ml), P. aeruginosa (MIC>80 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID20736034

Physicochemical Properties

Residues7
SequenceKWLKKWL
Molecular Weight1001.267
Grand Average of Hydropathy-0.843
Isoelectric Point10.302
Charge at pH 7.42.55
Secondary StructureHelix: 0.571, Turn: 0.000, Sheet: 0.286
Instability Index31.7
Aromaticity0.286

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