| ID | DRAMP04663 |
|---|---|
| Sequence | AKRLKKLAKKIWKWL |
| Length | 15 |
| Name | HPA3NT3-A1 (HPA3NT3 peptide analogs) |
| Source | Helicobacter pylori |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
| Pathogen | [Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=16 μM), Listeria monocytogenes(MIC=16 μM), Staphylococcus epidermidis(MIC=8 μM), Bacillus subtilis(MIC=8 μM);##Gram-negative bacteria : Escherichia coli(MIC=32 μM), Pseudomonas aeruginosa(MIC=32 μM), Primula vulgaris(MIC=8-16 μM), Salmonella typhimurium(MIC=8 μM);##Fungi : Candida albicans(MIC=16 μM), Trichosporon beigelii(MIC>128 μM), Aspergillus awamori(MIC=64 μM), Aspergillus flavus(MIC=64 μM), Aspergillus fumigatus(MIC=16 μM), Aspergillus parasiticus(MIC=16 μM) |
| Hemolytic Activity | [Ref.22982494] 20.9% hemolysis at 250 μM against human red blood cells |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 22982494 |
Physicochemical Properties
| Residues | 15 |
|---|---|
| Sequence | AKRLKKLAKKIWKWL |
| Molecular Weight | 1910.441 |
| Grand Average of Hydropathy | -0.68 |
| Isoelectric Point | 11.433 |
| Charge at pH 7.4 | 6.593 |
| Secondary Structure | Helix: 0.400, Turn: 0.000, Sheet: 0.333 |
| Instability Index | 22.313 |
| Aromaticity | 0.133 |
