Basic Information

IDDRAMP04676
SequenceMFTLKKPLLLLFFLGTISLSLCQEERDADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC
Length75
NameBrevinin-2HS2A
SourceOdorrana hainanensis (Odor frog) (Rana hainanensis)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.22450466]Gram-positive bacteria: S.aureus ATCC 25923 (MIC=19 µM), B.licheniformis X39 (MIC=37.5 µM) and R.rhodochrous X15 (MIC=9.5 µM);##Gram-negative bacterium: P. faecalis X29 (MIC=9.5 µM);##Fungi: C. albicans ATCC 2002 (MIC=19 µM), slime mold 090223 (MIC=37.5 µM).
Hemolytic Activity[Ref.22450466]LC50=300 μM against human erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot E7EKE0
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22450466

Physicochemical Properties

Residues75
SequenceMFTLKKPLLLLFFLGTISLSLCQEERDADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC
Molecular Weight8218.558
Grand Average of Hydropathy0.075
Isoelectric Point4.878
Charge at pH 7.4-3.797
Secondary StructureHelix: 0.320, Turn: 0.187, Sheet: 0.400
Instability Index46.465
Aromaticity0.04

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.