Basic Information

IDDRAMP04677
SequenceMFTMKKPLLLIVLLGIISLSLCEQERAADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC
Length75
NameBrevinin-2HS2B
SourceOdorrana hainanensis (Odor frog) (Rana hainanensis)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.22450466]Gram-positive bacteria: S.aureus ATCC 25923 (MIC=19 µM), B. licheniformis X39 (MIC=37.5 µM) and R. rhodochrous X15 (MIC=9.5 µM);##Gram-negative bacterium: P. faecalis X29 (MIC=9.5 µM);##Fungi: C. albicans ATCC 2002 (MIC=19 µM), slime mold 090223 (MIC=37.5 µM).
Hemolytic Activity[Ref.22450466]LC50=300 μM against human erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot E7EKE1
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22450466

Physicochemical Properties

Residues75
SequenceMFTMKKPLLLIVLLGIISLSLCEQERAADEEEGEMIEEEVKRSLLGTVKDLLIGAGKSAAQSVLKGLSCKLSKDC
Molecular Weight8122.582
Grand Average of Hydropathy0.231
Isoelectric Point5.075
Charge at pH 7.4-2.797
Secondary StructureHelix: 0.320, Turn: 0.187, Sheet: 0.413
Instability Index45.692
Aromaticity0.013

Similar Structure Search

Candidates based on structure

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