Basic Information

IDDRAMP18456
SequenceFSLIPSAIGGLISA
Length14
NamePepcon (peptide consensus sequence, synthetic)
SourceDesigned based on sequence alignment with scorpion linear peptides
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: S. epidermidis ATCC 12228 (MIC 7.5 uM),S. aureus (5 uM);##Gram-negative bacteria: E. coli ATCC 25922 (MIC 50 uM), S. enterica ATCC 10708 (60 uM), P. aeruginosa ATCC 27853 (40uM), A. baumannii ATCC 19606 (MIC 20 uM),K. pneumoniae (60 uM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID28096686

Physicochemical Properties

Residues14
SequenceFSLIPSAIGGLISA
Molecular Weight1345.583
Grand Average of Hydropathy1.621
Isoelectric Point5.525
Charge at pH 7.4-0.443
Secondary StructureHelix: 0.429, Turn: 0.429, Sheet: 0.286
Instability Index29.8
Aromaticity0.071

Similar Structure Search

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