Basic Information

IDDRAMP18495
SequenceQCRRLCYKQRCVTYCRGR
Length18
NameGomesin (Gm; Spiders, arachnids, Chelicerata, arthropods, invertebrates, animals)
SourceAcanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiparasitic, Antimalarial, Antic
Pathogen[Ref.10942757] Gram-positive bacteria: Aerococcus viridans (MIC=0.8-1.6 μM), Bacillus cereus (MIC=6.25-12.5 μM), Bacillus megaterium (MIC=0.2-0.4 μM), Bacillus thuringiensis (MIC=1.6-3.15 μM), Enterococcus faecalis (MIC=6.2-12.5 μM), Listeria monocytogenes (MIC=0.8-1.6 μM), Micrococcus luteus (MIC=0.4-0.8 μM), Pediococcus acidolacrici (MIC=3.15-6.25 μM), Staphylococcus aureus (MIC=1.6-3.15 μM), Staphylococcus epidermidis (MIC=0.8-1.6 μM), Staphylococcus haemolyticus (MIC=0.8-1.6 μM), Staphylococcus saprophyticus (MIC=0.8-1.6 μM), Streptococcus pyogenes (MIC=1.6-3.15 μM), Nocardia asteroides (MIC=1.6-3.15 μM);##Gram-negative bacteria: Escherichia coli 1106 (MIC=0.8-1.6 μM), Escherichia coli D22 (MIC=0.4-0.8 μM), Escherichia coli D31 (MIC=0.8-1.6 μM), Escherichia coli SBS363 (MIC=0.4-0.8 μM), Erwinia carolovora (MIC=3.15-6.25 μM), Enterobacter cloacae β12 (MIC=3.15-6.25 μM), Klebsiella pneumoniae (MIC=3.15-6.25 μM), Pseudomonas aeruginosa (MIC=1.6-3.15 μM), Salmonella thyphinurium (MIC=0.8-1.6 μM), Xhantomonas campestris pv. orizae (MIC=3.15-6.25 μM);##Fungi: Alternaria brassicola (MIC=0.4-0.8 μM), Aspergillus fumigatus (MIC=1.6-3.15 μM), Beauveria bassiana (MIC=12.5-25 μM), Fusarium culmorum (MIC=0.4-0.8 μM), Fusarium oxysporum (MIC=0.4-0.8 μM), Neurospora crassa (MIC=0.4-0.8 μM), Nectria haematococca (MIC=0.2-0.4 μM), Tricoderma viridae (MIC=0.4-0.8 μM), Tricophvton mentagrophytes (MIC=0.8-1.6 μM);##Yeasts: Candida albicans (MIC=0.15-0.3 μM), Candida glabrata (MIC=12.5-25 μM), Candida tropicalis (MIC=3.15-6.25 μM), Cryptococcus neoformans (MIC=0.8-1.6 μM), Saccharomyces cerevisiae (MIC=1.6-3.15 μM).
Hemolytic Activity[Ref.10942757] It exhibits 16% hemolysis at 1 μM and 100 μM against human erythrocytes
CytotoxicityNo cytotoxicity information found
N-terminal Modificationpyroglutamic acid
C-terminal ModificationAmidation
Linear/Cyclic/BranchedCyclic
Uniprot P82358
PDB 1KFP
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10942757

Physicochemical Properties

Residues18
SequenceQCRRLCYKQRCVTYCRGR
Molecular Weight2292.736
Grand Average of Hydropathy-1.061
Isoelectric Point9.931
Charge at pH 7.45.452
Secondary StructureHelix: 0.222, Turn: 0.056, Sheet: 0.056
Instability Index36.589
Aromaticity0.111

Similar Structure Search

Candidates based on structure

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