Basic Information
| ID | DRAMP21010 |
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| Sequence | KCRRYCYRQRCVTYCRGR |
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| Length | 18 |
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| Name | [G1K, L5Y, K8R]cGm (Derived from Gm) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor |
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| Pathogen | [Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=8 μM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=0.5-1 μM), Klebsiella pneumoniae ATCC 700603 (MIC=4-8 μM), Acinetobacter baumannii ATCC 19606 (MIC=1-2 μM), Pseudomonas aeruginosa ATCC 27853 (MIC<0.25-0.5 μM);##Fungi : Candida albicans ATCC 90028 (MIC=4 μM), Cryptococcus neoformans ATCC 208821 (MIC=0.5 μM) |
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| Hemolytic Activity | [Ref.28741926] 20.6-32% hemolysis at 64 μM against human red blood cells |
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| Cytotoxicity | [Ref.28741926] CC50 = 26.5 ± 2.4 μM against CRL-1739, CC50 = 2.0 ± 0.1 μM against MM96L, CC50 = 14.7 ± 1.5 μM against HFF-1, CC50 = 20.9 ± 1.4 μM against HeLa, CC50 = 15.2 ± 1.9 μM against MCF-7, CC50 = 1.3 ± 0.1 μM against K-562, CC50 = 15.7 ±1.1μM against HL-60;CC50=10.4 ± 1.0μM against PBMCs. |
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| N-terminal Modification | No specific N-terminal |
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| C-terminal Modification | No specific C-terminal |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28741926 |
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