Basic Information
| ID | DRAMP21004 |
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| Sequence | GCRRLCWRQRCVTWCRGR |
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| Length | 18 |
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| Name | [Y7W, K8R, Y14W]cGm (Derived from Gm) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor |
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| Pathogen | [Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 μM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=1 μM) |
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| Hemolytic Activity | [Ref.28741926] 42-49.8% hemolysis at 64 μM against human red blood cells |
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| Cytotoxicity | [Ref.28741926] CC50 = 31.6 ± 1.3 μM against CRL-1739, CC50 = 5.4 ± 0.3 μM against MM96L, CC50 = 31.3 ± 2.6 μM against HFF-1, CC50 = 41.0 ± 4.2 μM against HeLa, CC50 = 15.1 ± 1.4 μM against MCF-7, CC50 = 3.9 ± 0.1 μM against K-562. |
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| N-terminal Modification | No specific N-terminal |
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| C-terminal Modification | No specific C-terminal |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28741926 |
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