Basic Information
| ID | DRAMP02933 |
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| Sequence | RRWCFRVCYRGFCYRKCR |
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| Length | 18 |
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| Name | Polyphemusin-1 (PM1; crabs, Arthropods, animals) |
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| Source | Limulus polyphemus (Atlantic horseshoe crab) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | Gram-negative bacteria: Escherichia coli UB1005 (MIC=0.5 µg/ml), E. coli DC2 (MIC=1 µg/ml), Salmonella typhimurium (defensin-sensitive) (MIC=0.25 µg/ml), S. typhimurium (MIC=1 µg/ml), Pseudomonas aeruginosa K799 (MIC=2 µg/ml), P. aeruginosa Z61 (MIC=1 µg/ml);##Gram-positive bacteria: Staphylococcus aureus SAP0017 (MIC=2 µg/ml), Staphylococcus epidermidis (MIC=1 µg/ml), Enterococcus faecalis (MIC=1 µg/ml).##Yeasy: Candida albicans (MIC=4 µg/ml). |
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| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
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| Cytotoxicity | No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
P14215 |
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| PDB |
1RKK |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 2514185, 15134657 |
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