Basic Information
| ID | DRAMP02926 |
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| Sequence | KWCFRVCYRGICYRRCR |
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| Length | 17 |
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| Name | Tachyplesin I (Tac; TP1; Horseshoe Crab, arachnids, Chelicerata, arthropods, invertebrates, animals) |
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| Source | Tachypleus tridentatus (Japanese horseshoe crab) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Anti-HIV, Anti-cancer |
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| Pathogen | No MICs found in DRAMP database |
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| Hemolytic Activity | [Ref.29870123] 9.6% hemolytic activity at 8 μg/mL and 72.8% hemolytic activity at 512 μg/mL against human red blood cells. |
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| Cytotoxicity | [Ref.28429216]It possessed a cytotoxic effect on HL-60 cells (acutehuman promyelocytic leukemia cells) , K562 cells(myelogenous leukemia cells) , TSU cells (prostatecancer cells) . |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation (Arg17) |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
P14213 |
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| PDB |
1MA2, 1MA5, 6PIN, 1WO0, 1WO1, 2MDB, 2RTV |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 12369825, 2229025 |
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