Basic Information

IDDRAMP18511
SequenceKKLALLALKKWLPALKKLALLALKK
Length25
NameD-LAK120-P13
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial
Pathogen[Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.54±0.97 μM), Escherichia coli Top 10 (MIC=0.58±0.18 μM), Pseudomonas aeruginosa (MIC=1.42±0.41 μM);##Plasmodium: Plasmodium falciparum 3D7 (EC50=0.88±0.08 μM), Plasmodium falciparum C10 (EC50=2.18±0.41 μM), A549 (EC50=2.44±0.43 μM), RAW264.7 (EC50=3.80±0.34 μM)
Hemolytic Activity[Ref.22869378]HC50=11.66±0.03 μM against Not found (The literature does not mention)
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22869378

Physicochemical Properties

Residues25
SequenceKKLALLALKKWLPALKKLALLALKK
Molecular Weight2813.684
Grand Average of Hydropathy0.532
Isoelectric Point10.845
Charge at pH 7.47.537
Secondary StructureHelix: 0.440, Turn: 0.040, Sheet: 0.600
Instability Index12.964
Aromaticity0.04

Similar Structure Search

Candidates based on structure

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