| ID | DRAMP18552 |
|---|---|
| Sequence | KWKSFLKTFKKAVKTVLHTALKAISS |
| Length | 26 |
| Name | S11KL (V681 peptide derivative) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.15677462]Gram-positive bacteria: Staphylococcus aureus 25923 (MIC=32.0 μg/ml), Staphylococcus aureus SAP0017 (MIC=16.0 μg/ml), Staphylococcus epidermidis C621 (MIC=6.4 μg/ml), Bacillus subtilis C971 (MIC=3.2 μg/ml), Enterococcus faecalis C625 (MIC=32.0 μg/ml), Corynebacterium xerosis C875 (MIC=4.0 μg/ml), The geometric mean of MIC values above six Gram-positive strains (MIC=10.5 μg/ml);##Gram-negative bacteria: Escherichia coli UB1005 (MIC=10.1 μg/ml), Escherichia coli DC2 (MIC=4.0 μg/ml), Salmonella typhimurium C587 (MIC=25.4 μg/ml), Salmonella typhimurium C610 (MIC=8.0 μg/ml), Pseudomonas aeruginosa H187 (MIC=25.4 μg/ml), Pseudomonas aeruginosa H188 (MIC=32.0 μg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=13.7 μg/ml) |
| Hemolytic Activity | [Ref.15677462]MHC=4.0 μg/ml against human red blood cells |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 15677462 |
Physicochemical Properties
| Residues | 26 |
|---|---|
| Sequence | KWKSFLKTFKKAVKTVLHTALKAISS |
| Molecular Weight | 2961.588 |
| Grand Average of Hydropathy | -0.023 |
| Isoelectric Point | 10.778 |
| Charge at pH 7.4 | 6.577 |
| Secondary Structure | Helix: 0.346, Turn: 0.115, Sheet: 0.231 |
| Instability Index | 5.45 |
| Aromaticity | 0.115 |