Basic Information
| ID | DRAMP18583 |
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| Sequence | KWCFCVCYRGICYCRCRG |
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| Length | 18 |
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| Name | Tricystine cyclic cystine TP (ccTP, Tachyplesin-1 peptide derivative) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal |
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| Pathogen | [Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.0 μM in low-salt; MIC=0.8 μM in high-salt), Micrococcus luteus (MIC=0.5 μM in low-salt; MIC=0.4 μM in high-salt), Enterococcus faecalis (MIC=1.0 μM in low-salt; MIC=0.9 μM in high-salt);##Gram-negative bacteria: Escherichia coli (MIC=3.0 μM in low-salt; MIC=6.9 μM in high-salt), Pseudomonas aeruginosa (MIC=5.0 μM in low-salt; MIC=5.2 μM in high-salt), Primula vulgaris (MIC=6.0 μM in low-salt; MIC=14.4 μM in high-salt), Klebsiella oxytoca (MIC=2.1 μM in low-salt; MIC=7.8 μM in high-salt);##Fungi: Candida albicans (MIC=5.1 μM in low-salt; MIC=17.2 μM in high-salt), Candida kefyr (MIC=3.9 μM in low-salt; MIC=4.1 μM in high-salt), Candida tropicalis (MIC=5.2 μM in low-salt; MIC=1.1 μM in high-salt). |
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| Hemolytic Activity | [Ref.10673369] EC25=3800 μM against human red blood cells |
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| Cytotoxicity | No cytotoxicity information found |
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| N-terminal Modification | No specific N-terminal |
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| C-terminal Modification | No specific C-terminal |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 10673369 |
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