Basic Information

IDDRAMP18627
SequenceKLKKLLKKWLKLLKKLLK
Length18
NameD4-K9L8W (D-amino acid substitution of K9L8W)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.20363271]Gram-positive bacteria: Bacillus subtilis (MIC=1 μM), Staphylococcus epidermidis (MIC=2 μM), Staphylococcus aureus (MIC=2 μM);##Gram-negative bacteria: Escherichia coli (MIC=2 μM), Pseudomonas aeruginosa (MIC=2 μM), Salmonella typhimurium (MIC=2 μM).
Hemolytic Activity[Ref.20363271]HC50>800 μM against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID20363271

Physicochemical Properties

Residues18
SequenceKLKKLLKKWLKLLKKLLK
Molecular Weight2263.037
Grand Average of Hydropathy-0.311
Isoelectric Point10.903
Charge at pH 7.48.535
Secondary StructureHelix: 0.500, Turn: 0.000, Sheet: 0.444
Instability Index-26.15
Aromaticity0.056

Similar Structure Search

Candidates based on structure

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