Basic Information
| ID | DRAMP21250 |
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| Sequence | KKWRKLLKKLKKLL |
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| Length | 14 |
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| Name | PV3 (Derived from pEM-2 and MP-VT1) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=2.0 ± 1.7 mg/L, MBC=2.3 ± 1.5 mg/L), Enterococcus faecalis isolates(MIC=1.2 ± 0.8 mg/L, MBC=1.3 ± 0.6 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=1.0 ± 0.0 mg/L, MBC=1.3 ± 0.6 mg/L), Acinetobacter baumannii isolates(MIC=1.0 ± 0.0 mg/L, MBC=1.7 ± 0.6 mg/L) |
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| Hemolytic Activity | [Ref.27591703] 0% hemolysis at 64 μg/ml against human red blood cells; 10% hemolysis at 64 μg/ml against sheep red blood cells |
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| Cytotoxicity | [Ref.27591703] The cell viability of HEK293 cells induced by PV is 98.8%, 99.2%, 95.4%, 93.8%, 91.9%, 77.3% and 55.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 μg/mL within 24h. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 27591703 |
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