Basic Information
| ID | DRAMP21247 |
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| Sequence | KKWRWWLKALAKKLL |
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| Length | 15 |
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| Name | PV (Derived from pEM-2 and MP-VT1) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=0.5 ± 0.0 mg/L, MBC=0.5 ± 0.0 mg/L), Enterococcus faecalis isolates(MIC=0.7 ± 0.3 mg/L, MBC=0.8 ± 0.3 mg/L);##Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=1.2 ± 0.8 mg/L, MBC=1.3 ± 0.6 mg/L), Acinetobacter baumannii isolates(MIC=0.4 ± 0.1 mg/L, MBC=0.5 ± 0.0 mg/L) |
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| Hemolytic Activity | [Ref.27591703] 0% hemolysis at 32 μg/ml , 5% hemolysis at 64 μg/ml against human red blood cells; 0% hemolysis at 32 μg/ml , 8% hemolysis at 64 μg/ml against sheep red blood cells |
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| Cytotoxicity | [Ref.27591703] The cell viability of HEK293 cells induced by PV is 98.8%, 97.4%, 85.8%, 56.2%, 22.8%, 12.2% and 2.3% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 μg/mL within 24h. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 27591703 |
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