Basic Information

IDDRAMP18667
SequenceKETWWETWWTEWSQPKKKRKV
Length21
NamePep-1
SourceDerived from the nuclear localization sequence of simian virus 40 large T antigen and from reverse t
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.16945333]Gram-positive bacteria: Bacillus subtilis (KCTC 3068) (MIC=8.0 μM), Staphylococcus aureus (KCTC 1621) (MIC=64.0 μM), Staphylococcus epidermidis (KCTC 1917) (MIC=64.0 μM);##Gram-negative bacteria: Escherichia coli (KCTC 1682) (MIC=32.0 μM);##Antibiotic-resistant bacteria: MDRPA 1 (CCARM 2092) (MIC=32.0 μM), MDRPA 3 (CCARM 2109) (MIC=32.0 μM).
Hemolytic Activity[Ref.16945333]Non-hemolysis at 200 μM against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16945333

Physicochemical Properties

Residues21
SequenceKETWWETWWTEWSQPKKKRKV
Molecular Weight2848.218
Grand Average of Hydropathy-2.038
Isoelectric Point9.823
Charge at pH 7.42.548
Secondary StructureHelix: 0.286, Turn: 0.095, Sheet: 0.143
Instability Index19.89
Aromaticity0.238

Similar Structure Search

Candidates based on structure

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