Basic Information

IDDRAMP20820
SequenceFRIRVRV
Length7
NameFV7
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.28178190] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=64 μM), Streptococcus Faecalis ATCC 29212 (MIC=32 μM), Bacillus subtilis CMCC 63501 (MIC=16 μM), Staphylococcus epidermidis ATCC 12228 (MIC=32 μM);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=16 μM), Escherichia coli UB 1005 (MIC=32 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=16 μM), Pseudomonas aeruginosa PAO1 (MIC=32 μM), Salmonella typhimurium ATCC 14028 (MIC=16 μM), Salmonella typhimurium ATCC 7731 (MIC=32 μM).
Hemolytic Activity[Ref.28178190] 3% hemolysis at 128 μM against human red cells
Cytotoxicity[Ref.28178190] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID28178190

Physicochemical Properties

Residues7
SequenceFRIRVRV
Molecular Weight945.166
Grand Average of Hydropathy0.314
Isoelectric Point12
Charge at pH 7.42.557
Secondary StructureHelix: 0.571, Turn: 0.000, Sheet: 0.000
Instability Index8.571
Aromaticity0.143

Similar Structure Search

Candidates based on structure

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