Basic Information

IDDRAMP20925
SequenceGIRDILKYGKPS
Length12
NameMH3R
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.24957834] Gram-negative bacteria: Escherichia coli (MIC =5 microM), Pseudomonas aeruginosa (MIC =20 microM), S. Salmonella typhimurium (MIC =5 microM), Klebsiella pneumoniae (MIC =5 microM) ;## Gram-positive bacteria: Staphylococcus aureus (MIC =10 microM)
Hemolytic Activity[Ref.24957834] Some peptides at 50 μM led to about 10% hemolysis against human red blood cells, but in general, negligible hemolytic activity is observed even at 100 μM and 200 μM peptide.
Cytotoxicity[Ref.24957834] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID24957834

Physicochemical Properties

Residues12
SequenceGIRDILKYGKPS
Molecular Weight1346.574
Grand Average of Hydropathy-0.625
Isoelectric Point9.7
Charge at pH 7.41.55
Secondary StructureHelix: 0.333, Turn: 0.333, Sheet: 0.083
Instability Index6.683
Aromaticity0.083

Similar Structure Search

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