Basic Information

IDDRAMP21143
SequenceGIHHILKYGKPS
Length12
NameMyxinidin1 (Derived from Myxinidin)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.26450121] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC>32 μM), Staphylococcus aureus CCARM 3114(MIC>32 μM), Staphylococcus aureus CCARM 3709(MIC>32 μM), Listeria monocytogenes (KCTC 3710)(MIC>32 μM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC>32 μM), Escherichia coli CCARM 1229(MIC>32 μM), Escherichia coli CCARM 1238(MIC>32 μM), Salmonella typhimurium (KCTC 1926)(MIC>32 μM), Salmonella typhimurium CCARM 8009(MIC>32 μM), Salmonella typhimurium CCARM 8013(MIC>32 μM), Pseudomonas aeruginosa (ATCC 27853)(MIC>32 μM), Pseudomonas aeruginosa 3592(MIC>32 μM), Pseudomonas aeruginosa 5018(MIC>32 μM)
Hemolytic Activity[Ref.26450121] 0% hemolysis at 50 μM , 0% hemolysis at 100 μM , 0% hemolysis at 200 μM , 0% hemolysis at 400 μM against human red blood cells
Cytotoxicity[Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 μM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID26450121

Physicochemical Properties

Residues12
SequenceGIHHILKYGKPS
Molecular Weight1349.58
Grand Average of Hydropathy-0.492
Isoelectric Point9.703
Charge at pH 7.41.623
Secondary StructureHelix: 0.333, Turn: 0.333, Sheet: 0.083
Instability Index53.583
Aromaticity0.083

Similar Structure Search

Candidates based on structure

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