Basic Information
| ID | DRAMP20933 |
|---|
| Sequence | FFSLIPSLVGGLISAFK |
|---|
| Length | 17 |
|---|
| Name | Stigmurin |
|---|
| Source | Tityus stigmurus |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiparasitic, Antiproliferative |
|---|
| Pathogen | [Ref.29670004] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=9.38 μM), Staphylococcus epidermidis ATCC 122225 (MIC=9.38 μM);##yeasts: Candida albicans ATCC 90028 (MIC=37.5 μM);##Stigmurin inhibit 90% of the epimastigote forms of Trypanosoma cruzi growth at 25 ?M;##HeLa cell line: IC50=7.98 μM |
|---|
| Hemolytic Activity | [Ref.29670004]Hemolysis 0% at 1.17 μM, hemolysis 1% at 2.34 μM, hemolysis 1% at 4.69 μM, hemolysis 0% at 9.38 μM, hemolysis 1% at 18.75 μM, hemolysis 1% at 37.50 μM, hemolysis 3% at 75.00 μM against human red blood cell |
|---|
| Cytotoxicity | [Ref.29670004] The cell viability of HeLa cell lines is 56%, 66%, 66%, 81%, 78%, 66% and 30% at peptide concentrations of 2, 4, 8, 10, 15, 20 and 40 μM. ##The cell viability of 3T3 cell lines is 81%, 63%, 51%, 29%, 27%, 19% and 15% at peptide concentra |
|---|
| N-terminal Modification | Free |
|---|
| C-terminal Modification | Amidation |
|---|
| Linear/Cyclic/Branched | Linear |
|---|
| Uniprot |
|
|---|
| PDB |
|
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 29670004 |
|---|
