Basic Information

IDDRAMP20953
SequenceFLGELWNVWKSVF
Length13
Name[E]4[W]9-VmCT1-NH2 VmCT1 petide derivative
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial
Pathogen[Ref.27912176] Gram-negative bacteria: Escherichia coli (SBS 363)(MIC=12.5μmol/L);Pseudomonas aeruginosa (ATCC 27853)(MIC=3.12μmol/L);Escherichia coli (D31)(MIC=6.25μmol/L);Serratia marcescens (ATCC 4112)(MIC=3.12μmol/L);Enterobacter cloacae (beta-12)(MIC=50μmol/L);##Gram-positive bacteria: Micrococcus luteus (A270)(MIC=3.12μmol/L);Staphylococcus aureus (ATCC 29213)(MIC=12.5μmol/L);Bacillus subtilis (ATCC 6633)(MIC=12.5μmol/L);Staphylococcus epidermidis (ATCC 12228)(MIC=6.25μmol/L);##Fungi: Candida albicans MDM8(MIC=6.25μmol/L);Candida tropicalis (IOC 4560)(MIC=12.5μmol/L);##Cryptococcus neoformans(MIC=6.25μmol/L)
Hemolytic Activity[Ref.27912176] MHC=1.60μmol/L against human red blood cells
Cytotoxicity[Ref.27912176] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID27912176

Physicochemical Properties

Residues13
SequenceFLGELWNVWKSVF
Molecular Weight1624.877
Grand Average of Hydropathy0.592
Isoelectric Point6.001
Charge at pH 7.4-0.444
Secondary StructureHelix: 0.615, Turn: 0.231, Sheet: 0.231
Instability Index31.138
Aromaticity0.308

Similar Structure Search

Candidates based on structure

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