| ID | DRAMP20951 |
|---|---|
| Sequence | FLGALWEVAKSVF |
| Length | 13 |
| Name | [E]7-VmCT1-NH2 VmCT1 petide derivative |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial |
| Pathogen | [Ref.27912176] Gram-negative bacteria: Escherichia coli (SBS 363)(MIC=1.56μmol/L);Pseudomonas aeruginosa (ATCC 27853)(MIC=0.78μmol/L);Escherichia coli (D31)(MIC=1.56μmol/L);Serratia marcescens (ATCC 4112)(MIC=1.56μmol/L);Enterobacter cloacae (beta-12)(MIC=25μmol/L);##Gram-positive bacteria: Micrococcus luteus (A270)(MIC=1.56μmol/L);Staphylococcus aureus (ATCC 29213)(MIC=6.25μmol/L);Bacillus subtilis (ATCC 6633)(MIC=12.5μmol/L);Staphylococcus epidermidis (ATCC 12228)(MIC=6.25μmol/L);##Fungi: Candida albicans MDM8(MIC=12.5μmol/L);Candida tropicalis (IOC 4560)(MIC=12.5μmol/L);Candida parapsilosis (IOC 4564)(MIC=50μmol/L);##Aspergillus niger(MIC=25μmol/L);##Cladosporium herbarum (ATCC 26362)(MIC=25μmol/L);##Cryptococcus neoformans(MIC=6.25μmol/L) |
| Hemolytic Activity | [Ref.27912176] MHC=1.60μmol/L against human red blood cells |
| Cytotoxicity | [Ref.27912176] No cytotoxicity information found |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Linear/Cyclic/Branched | Linear |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 27912176 |
Physicochemical Properties
| Residues | 13 |
|---|---|
| Sequence | FLGALWEVAKSVF |
| Molecular Weight | 1466.721 |
| Grand Average of Hydropathy | 1.208 |
| Isoelectric Point | 6.001 |
| Charge at pH 7.4 | -0.444 |
| Secondary Structure | Helix: 0.538, Turn: 0.154, Sheet: 0.385 |
| Instability Index | 20.915 |
| Aromaticity | 0.231 |
