Basic Information
| ID | DRAMP21009 |
|---|
| Sequence | GCRRLCYKQRCVTYCRGpPR |
|---|
| Length | 20 |
|---|
| Name | [D-P L-P]cGm (Derived from Gm) |
|---|
| Source | Synthetic construct |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor |
|---|
| Pathogen | [Ref.28741926]Gram-positive bacteria : Staphylococcuss aureus ATCC 25923 (MIC=16 μM);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=4 μM), Klebsiella pneumoniae ATCC 700603 (MIC=1-4 μM), Acinetobacter baumannii ATCC 19606 (MIC=1-4 μM), Pseudomonas aeruginosa ATCC 27853 (MIC=4 μM);##Fungi : Candida albicans ATCC 90028 (MIC=8 μM), Cryptococcus neoformans ATCC 208821 (MIC=0.5-1 μM) |
|---|
| Hemolytic Activity | [Ref.28741926] 41.5-44.9% hemolysis at 64 μM against human red blood cells |
|---|
| Cytotoxicity | [Ref.28741926] CC50 = 22.5 ± 3.3 μM against CRL-1739, CC50 = 3.0 ± 0.1 μM against MM96L, CC50 = 14.9 ± 0.8 μM against HFF-1, CC50 = 51.5 ± 3.9 μM against HeLa, CC50 = 3.9 ± 0.2 μM against K-562, CC50 = 14.1 ± 0.9 μM against PBMCs |
|---|
| N-terminal Modification | No specific N-terminal |
|---|
| C-terminal Modification | No specific C-terminal |
|---|
| Linear/Cyclic/Branched | Cyclic |
|---|
| Uniprot |
|
|---|
| PDB |
|
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 28741926 |
|---|
