Basic Information
| ID | DRAMP21081 |
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| Sequence | KWCFRVCYAGICYRRCA |
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| Length | 17 |
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| Name | TP1[R9A, R17A] (Derived from TP1) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.28960954] Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.06 μg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=2 μg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.03 μg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.06 μg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 μg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=0.5 μg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=4 μg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.25 μg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 μg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=0.5 μg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=2 μg/ml);##Fungi : Candida albicans ATCC 90028(MIC=8 μg/ml), Cryptococcus neoformans ATCC 208821(MIC=0.5 μg/ml) |
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| Hemolytic Activity | [Ref.28960954] MHC10=0.2 μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 μg/ml. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28960954 |
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