Basic Information
| ID | DRAMP21145 |
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| Sequence | RIRWILRYWRWS |
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| Length | 12 |
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| Name | Myxinidin3 (Derived from Myxinidin) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.26450121] Gram-positive bacteria : Staphylococcus aureus (ATCC 25923)(MIC=1 μM), Staphylococcus aureus CCARM 3114(MIC=8 μM), Staphylococcus aureus CCARM 3709(MIC=2 μM), Listeria monocytogenes (KCTC 3710)(MIC=4 μM);##Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2 μM), Escherichia coli CCARM 1229(MIC=1 μM), Escherichia coli CCARM 1238(MIC=2 μM), Salmonella typhimurium (KCTC 1926)(MIC=2 μM), Salmonella typhimurium CCARM 8009(MIC=4 μM), Salmonella typhimurium CCARM 8013(MIC=4 μM), Pseudomonas aeruginosa (ATCC 27853)(MIC=4 μM), Pseudomonas aeruginosa 3592(MIC=8 μM), Pseudomonas aeruginosa 5018(MIC=8 μM) |
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| Hemolytic Activity | [Ref.26450121] 27% hemolysis at 50 μM , 45% hemolysis at 100 μM , 63% hemolysis at 200 μM , 59% hemolysis at 400 μM against human red blood cells |
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| Cytotoxicity | [Ref.26450121] The cell survial rates of normal human keratinocytes (NHK) are 100%, 95.8%, 88.3%, 83.4%, 77.4% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50, 100 μM. Melittin, the control, induced 100% toxicity against NHKs at a concentration of |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 26450121 |
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