Basic Information

IDDRAMP21197
SequenceGLTFLKKILNFAKKIYTAIW
Length20
NameGW-H3 (De novo synthesis)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.18586467] Gram-positive bacteria : Staphylococcus aureus (BCRC 10780)(MIC=16 μg/ml), Staphylococcus xylosus (BCRC 12930)(MIC=16 μg/ml), Staphylococcus aureus (BCRC 10781)(MIC=16 μg/ml), Listeria monocytogenes (BCRC 14845)(MIC=8 μg/ml), Streptococcus bovis (BCRC 14729)(MIC=128 μg/ml), Streptococcus iniae (laboratory strain)(MIC=32 μg/ml), Lactococcus garvieae (laboratory strain)(MIC=32 μg/ml);##Gram-negative bacteria : Klebsiella oxytoca (BCRC 13985)(MIC=128 μg/ml), Pseudomonas aeruginosa (BCRC 10944)(MIC=32 μg/ml), Escherichia coli (BCRC 10675)(MIC=32 μg/ml), Enterobacter aerogenes (BCRC 10370)(MIC=16 μg/ml), Enterobacter cloacae (BCRC 10401)(MIC=16 μg/ml), Yersinia enterocolitica (BCRC 13999)(MIC=64 μg/ml)
Hemolytic Activity[Ref.18586467] MHC=8 μM against human red blood cells
Cytotoxicity[Ref.18586467] No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18586467

Physicochemical Properties

Residues20
SequenceGLTFLKKILNFAKKIYTAIW
Molecular Weight2368.898
Grand Average of Hydropathy0.55
Isoelectric Point10.177
Charge at pH 7.43.545
Secondary StructureHelix: 0.500, Turn: 0.100, Sheet: 0.250
Instability Index0.805
Aromaticity0.2

Similar Structure Search

Candidates based on structure

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