Basic Information

IDDRAMP21224
SequenceVRRPkWWWkFLRR
Length13
NameTPk (Derived from TP)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.17604338] Gram-positive bacteria : Staphylococcus epidermidis(KCTC 1917)(MIC=1 μM), Staphylococcus aureus(KCTC 1621)(MIC=1 μM), MRSA1 (CCARM 3001)(MIC=1 μM), MRSA2 (CCARM 3543)(MIC=0.5 μM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=2 μM), Pseudomonas aeruginosa(KCTC 1637)(MIC=4 μM), MDRPA1 (CCARM 2095)(MIC=4 μM), MDRPA2 (CCARM 2109)(MIC=8 μM)
Hemolytic Activity[Ref.17604338] MHC10>200 μM against human red blood cells
Cytotoxicity[Ref.17604338] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17604338

Physicochemical Properties

Residues13
SequenceVRRPkWWWkFLRR
Molecular Weight1914.31
Grand Average of Hydropathy-1.485
Isoelectric Point12
Charge at pH 7.45.518
Secondary StructureHelix: 0.462, Turn: 0.077, Sheet: 0.077
Instability Index126.985
Aromaticity0.308

Similar Structure Search

Candidates based on structure

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